EDECMO 25 – ‘Ze ECMO TEAM.’ Manning and Lamhaut: Updates on ECMO, the new 7F REBOA Catheter, and Pre-hospital ECMO in France

In this episode, Zack interviews Jim Manning MD (University of North Carolina) and Dr. Lionel Lamhaut of the famed French SAMU (Service d'Aide Médicale Urgente).

Highlights:

2015 Resuscitation Science Symposium updates:

“ECMO is at the forefront of resuscitation science” – Jim Manning

The New REBOA Catheter: Pryor Medical – just obtained FDA approval for endovascular proximal control of non-compressible hemorrhage below the diaphragm.

At Sharp Memorial Hospital we currently use the 12Fr Chek-Flo sheath, paired with 12F (external diameter) CODA balloon occlusion catheter for non-compressible hemorrhage below the diaphragm.  Pryor Medical has just gained FDA approval to market their REBOA catheter – a 7F version that doesn't seem to require surgical repair of the arteriotomy site.  For those of us doing REBOA, this is a BIG DEAL:

Website Image 10-26-15

Selective Aortic Arch Perfusion Catheter (SAAP) – which is like a REBOA catheter but has a lumen large enough to perfuse blood (or a blood substitute) through.  Manning talks about what's sexy with his device.

 

Lionel Lamhaut from the French SAMU (Service d'Aide Médicale Urgente) gives us an update on their prehospital ECMO program in France:

SAMU Inclusion Criteria:

  1. Medical Cardiac Arrest
  2. Age < 75
  3. No Flow < 5 min (bystander CPR must be started within 5 min)
  4. Hypothermia is always considered
  5. Intoxications (of any kind) are always considered
  6. ETCO2 > 10

For review, check out our original discussion with ‘reanimateur' Dr. Lamhaut about prehospital ECMO: edecmo.org/17

In keeping with all of the in-hospital and out-of-hospital ECPR data accumulating, it appears that Lamhaut's team is also seeing a success rate (survival with CPC 1 or 2) of around 30% (final data pending publication).

 

Consider this: the modified cut-down technique. The French prehospital team, quite obviously, don't have ultrasound access in the field.  So instead of using ultrasound visualization of the femoral vessels, they necessarily use direct visualization.  Listen to this episode to hear the details…

 

 

 

 

EDECMO 24 – Weaning VA-ECMO, with Deirdre Murphy

In this episode, Zack and Joe talk with Deirdre Murphy, the Deputy Director of the ICU, director of the cardiothoracic ICU at the Alfred Hospital in Melbourne, Australia. The Alfred has put itself on the map in so many ways over the past decade. Home to Stephen Bernard (of the original Hypothermia after ROSC without RONF fame), Chris Nickson (@precordialthump, @ragepodcast, @intensiveblog, #SMACC, lifeinthefastlane.com), and good friends Jason McClure, Steve McGloughlin, Josh Ihle, Paul Nixon, and Deirdre Murphy, The Alfred is becoming a mecca for advanced resuscitation and ECMO/ECPR.  In this episode we sat down with Dr. Murphy to discuss the nuances of weaning a patient from ECMO.

As ED Docs, Zack and I find ourselves at the heroic end of the resuscitation spectrum when the dying patient goes on pump…but what happens at the other end? What happens in the hours, days, and weeks that follow?  Listen to this episode to find out…

 

Deirdre Murphy MB (Hons), MRCPI, FCARCSI, FCICM, DDU (Crit Care), PGDipEcho

Deirdre Murphy MB (Hons), MRCPI, FCARCSI, FCICM, DDU (Crit Care), PGDipEcho

Deirdre Murphy MB (Hons), MRCPI, FCARCSI, FCICM, DDU (Crit Care), PGDipEcho

Deirdre is Deputy Director ICU, Director of the Cardiothoracic ICU at The Alfred Hospital with particular interests in echocardiography and cardiac intensive care, especially mechanical circulatory supports including Ventricular Assist Devices and ECMO. Deirdre originally trained in Ireland with postgraduate training in general medicine and anaesthesia prior to undertaking intensive care training in Australia in 1999. She has been an Intensivist at The Alfred since 2003. Deirdre has been using echo in clinical practice since 2002 and heads the ICU echocardiography programme at the Alfred. She is convenor of the Alfred Critical Care Echocardiography Course and the Alfred TOE course and teaches on many of the other Alfred courses including the Ultrasound, ECMO and HeART courses.

A paper just published in Intensive Care Medicine followed this algorithm:

(Intensive Care Med (2015) 41:902-905)

How to wean a patient from veno-arterial extracorporeal membrane oxygenation

Screen Shot 2015-09-07 at 12.26.16 PM

Some Notes

Signs of improvement

  • Pulsatility indicates the patient is getting better
  • ETCO2 starts to rise
  • Weaning Vasopressors

 

Want More??

Check out Dr. Murphy's talk from smaccGOLD on “ECMO: What could go wrong?”

Also, check out the incredible resources on ECMO on the INTENSIVE blog (the Alfred ICU Education blog)

Update:

Can we use ETCO2 to assess weaning?

snag-0002-2

 

EDECMO 23 – ORNATO LIVES! – How ECMO Saved a Pillar of Resuscitation

Dept of Emergency Medicine_Joseph Ornato_MD

Dept of Emergency Medicine. Joseph Ornato MD

“They RSI'd me…they cannulated me…

Here I am today, two months later…”

Joe Ornato, a pillar in the world of resuscitation, suffered a massive PE and arrested upon arrival to the Virginia Commonwealth University Emergency Department in April 2015.  First: hats off!!! to the Emergency Department, the resuscitation team, the CT surgeons and entire staff at VCU. How it all unfolded is amazing! You MUST listen to this episode to hear the details…

Joseph P. Ornato, MD, FACP, FACC, FACEP

Dr. Joseph P. Ornato is professor and chairman of the Department of Emergency Medicine at Virginia Commonwealth University Medical Center in Richmond, Virginia. He is also medical director of the Richmond Ambulance Authority, the Prehospital Paramedic System serving Richmond, Va. Dr. Ornato is triple board certified (internal medicine, cardiology, emergency medicine) and is an active researcher in the field of cardiopulmonary resuscitation. Dr. Ornato is an editor of the journal Resuscitation. He is past Chairman of the American Heart Association's (AHA) National Emergency Cardiovascular Care Committee and its Advanced Cardiac Life Support Subcommittee. He chaired the National Steering Committee on the NIH Public Access Defibrillation Trial. He is currently consultant and cardiac co-chairman of the NIH Resuscitation Outcomes Consortium (ROC) and serves as principal investigator for VCU on the NIH-sponsored Neurological Emergency Treatment Trials (NETT) Network. Dr. Ornato is a member of the Institute of Medicine.

Ornato and EMS team

Dr. Ornato and the prehospital trauma team

joe-ornato-photo-4_10937792

 

We lose the equivalent of one medium sized American city to the problem of sudden, unexpected cardiac arrest each year. The best weapon we have against this killer is early defibrillation. We need to move quickly to saturate the chain of survival, particularly the early defibrillation  component, in every community.”

-Joe Ornato, MD, FACC, FACEP

EDECMO 22 – Managing the Crashing Tox Patient with ECMO – with Leon Gussow & Steve Aks from The Poison Review

 

…the key thing is to put them on ECMO when they need it, but not a minute sooner!

-Leon Gussow

In this episode Scott, Zack and Joe were all in the same room…in a conference room at the University of North Carolina, Chapel Hill – where we were doing ECPR studies in an animal model of cardiac arrest with Jim Manning. We spoke with legendary toxicologists Leon Gussow and Steve Aks about the role of ECMO and ECPR in the overdosed tox patient.

This is a fascinating discussion about the nuances of ECMO in the crashing intoxicated patient.

Check out THE POISON REVIEW and Subscribe to them in iTunes

GussowLeon Gussow MD,

University of Illinois Medical Center, Chicago
John H. Stroger Jr. Hospital of Cook County
Emergency Medicine News “Toxicology Rounds”
Medical Editor of ‘The Poison Review”

aks-1-186x250

Steve Aks DO, FACMT, FACOEP, FACEP

Director, Toxicology Fellowship Program, Department of Emergency Medicine, Cook County Health and Hospitals System


 

Some Unique Situations:

ECMO and intralipid?

  • What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient. Clin Toxicol (Phila). 2015 Mar;53(3):145-50. doi: 10.3109/15563650.2015.1004582. Epub 2015 Jan 29.
  • Bolus dose intralipid before ECMO is reasonable and should not result in significant pump complications with our current oxygenators.  However, starting intra-lipid after the patient is on bypass won't likely provide much more benefit and could shorten the life of your oxygenator.

ECMO and Dialysis?

  • Hemodialysis can be done in-line with the ECMO circuit, but its preferred to use a separate dialysis catheter placed at a remote site (ie the IJ).  A dialysis circuit CAN be spliced into the ECMO circuit, but is a little more complicated.

Mitochondrial and Cellular Respiration Poisons (dinitrophenol & Cyanid) and Carbon Monoxide?

  • ECMO is of NO USE in these intoxications.

EDECMO 21- The Vienna Project: A Randomized-Controlled Trial of ECPR for Out-Of-Hospital Cardiac Arrest


SchoberAndreas Schober is an Emergency Medicine physician and resuscitationist from the Medical University of Vienna. Dr. Schober is a world-expert in resuscitation, ECPR, and cardiac arrest. We met Schober in Chicago at the 2014 American Heart Association (AHA) Resuscitation Symposium (ReSS) where he presented their experience with a “Load & Go” model for out-of-hospital cardiac arrest (OHCA): Screen Shot 2015-05-01 at 10.08.03 PM


In this episode Zack talks with Dr. Schoeber about their newest endeavor, the holy grail: a randomized-controlled trial comparing “Load & Go” (transporting OHCA patients to the ED immediately for consideration of ECMO) vs. “standard care” (staying on scene until the patient achieves either ROSC or is pronounced dead).  Zack and Andreas talk about the impact this could have on the future of ECPR for OHCA.

Announcements:

SMACC Chicago 2015: There is still time to register for SMACC – the biggest and baddest ED Critical Care conference in the World. Just check out the lineup of speakers! You won't want to miss this.

Reanimate San Diego 2016:  The EDECMO team has put together a crew of world-class educators to teach you how to set up an ED ECMO program, teach you how to initiate ECPR in arresting patients, and teach you how to manage patients after they are on “on-pump”. Please join us in “America's Finest City,” San Diego, California, for 2-day immersion in ECPR. We are limiting the conference size to maximize your learning experience, so registration will sell out quickly:

Register for Reanimate San Diego 2016

 

**Special thanks to Camille Hudon for providing the “International Introduction”, in French, to this episode!!!  That was recorded in a small restaurant in Montreal during Bring Me Back To Life 2014

 

 

EDECMO 20 – The Golden Hour & the Rule of 3’s: Optimizing the Critical First Hour on Heart-Lung Bypass

Announcements

Upcoming Conferences:

  1. SMACC 2015: June 23-26, 2015. The biggest and baddest critical care conference of the year is in Chicago this year.
  2. Essentials of Emergency Medicine 2015. October 13-15, 2015. The Big Show. In Vegas. At the Cosmopolitan.
  3. Reanimate San Diego. February 25-26, 2016. The essentials of ECMO in 2 glorious days. Here is a sneak peak at the Reanimate 2016 Promo Video.

Flipped Classroom SMACC ECMO Workshop 2015

For those taking the upcoming ECMO courses with us, download both of these 2 attachments. The first is a diagram of a traditional ECMO circuit – its nice to print this out and follow along. Not every circuit is the same and we have ours custom built by Maquet.  The second is a self-study course.  While it isn't necessary to review these before our workshop, it will really put you ahead of the game and we focus more on procedures.

Custom Maquet Circuit

Figure 1. The Custom Maquet ECMO Circuit

Study Guide

Screen Shot 2015-04-04 at 11.04.36 PM

Review of the 3 stages of ECPR

  1. STAGE 1: Placement of any commercially available vascular catheter in the femoral vein and femoral artery
  2. STAGE 2: Replacement of each catheter with ECMO cannulae. Checkout EDECMO 5: Cognitive Task Management for ED ECMO Stages 1 and 2. Also, we learned several cannulation pearls from Stephen Bernard in EDECMO 14 Part 1 and Part 2
  3. STAGE 3: Initiation of Total Heart Lung Bypass

ECMO Circuit Setup:

  1. Plug in the machine and power-on the heater-cooler and the Rotaflow console.
  2. Unpackage the circuit and hold it up to orient yourself.
  3. Mounting the Rotaflow Pump to the Pump Drive

    Mounting the Rotaflow Pump to the Pump Drive

    Attach the Oxygenator to the bracket and the pump to the pump-drive; hang the distal ends of the circuit (the tubes that will connect to the patient) from the IV pole.

  4. Apply ultrasonic contact cream to the flow probe contact site
  5. Remove and DISCARD the yellow de-airing exit port cap on the top of the oxygenator.
  6. Connect the water lines from the heater-cooler to the Quadrox Oxygenator & open the stopcocks.
  7. “Run the circuit”, making sure that the recirculation bridge is OPEN, arterial and venous tubing is CLAMPED, rapid-prime tubes are CLAMPED, both of the blood sampling “pig tail” stopcocks are CLOSED.
  8. PRIME the circuit:  Priming the Circuit: Filling the ECMO circuit (tubing, pump, oxygenator) with crystalloid priming solution (ie Isolyte), adding 2,500 units of heparin to each 1-liter bag of priming solution.  We discuss the finer details of this with Greg Griffin, the Chief Perfusionist at the University of North Carolina, Chapel Hill in EDECMO 8.
    1. squeeze all air out of prime bag INTO the circuit and then hang those bags from the IV pole.
    2. Open the ratchet clamps: the circuit will fill (prime) by gravity.
  9. Connect the Oxygen supply line (from Oxygen tank) to the Oxygen inlet port on the oxygenator
  10. De-air the circuit:
    1. Remove the patient-lines that are hanging from the IV pole and drop them below the fluid level of the IV bags to prime them. ratchet-clamp them closed. Now the entire circuit has been primed.
    2. Open the recirculation bridge and briefly increase the RPM on the Rotaflow Console until the pump is running at 4LPM for 15 seconds. This will de-air the circuit as air is release from the de-ar exit port on the Oxygenator.  ***Some air may still be trapped in the pump though. So…
    3. Turn the RPM on the Rotaflow console to zero. Allow any air in the pump head to flow into the PVC tubing between the pump head and the oxygenator and then return the RPM to 4LPM to complete the de-airing process.
  11. Calibrate the flow-probe: Reduce pump speed to zero RPM, clamp off the recirculation bridge and “ZERO” the flow probe by pushing the “ZERO” button for a few seconds. The console will beep.

Initiation of Total Heart Lung Bypass (STAGE 3)

Maquet-Circuit-mockup.001So you've cannulated your patient while your ECMO-nurse has primed the circuit with crystalloid.  Connect the venous and arterial PVC lines from the circuit to the ECMO cannulas in the patient. And since this is STAGE 3, we've established the EDECMO “Rule of 3's.”  There are 3 things you need remember before, during, and after you've initiated heart-lung bypass.

A.  3 Critical First Steps BEFORE initiating bypass:

  1. Heparinize the patient = 5,000 units IV bolus
    1. Heparin 2,500 units in each liter of priming solution
    2. Bioline coating
    3. ACT > 200 seconds
  2. Attach O2 source (@ 4-6 LPM) to the Oxygenator
  3. No open central lines (CVP, Swan-Ganz, etc).

CLOSE the Recirculation Bridge and OPEN the venous and arterial ratchet clamps. Turn up the RPM on the Rotaflow console. Your patient is on heart-lung bypass.

B.  3 Critical things to confirm JUST AFTER your patient is on bypass:

  1. The arterial line should have bright red (oxygenated) blood and the venous line should be dark-red.
    1. IF you see BRIGHT-BRIGHT, you've incorrectly placed both cannulas in the same vessel.
    2. If you see DARK-DARK, there is a problem with the oxygenator. Confirm your O2 supply to the oxygenator.
  2. Your cannulas are secured to the skin with suture and tape.
  3. The recirculation bridge is CLOSED.

C.  3 Critical Values to Optimize ECMO

1. Optimize Blood Flow:

  • Establish the MAXIMUM blood flow (LPM) at the lowest RPM. GOAL = 60 ml/kg
  • Increase the RPM on the Rotaflow console until:
    1. Any further increases in RPM does not result in increased blood flow (LPM).
    2. The circuit begins to “Chatter.”
    3. SvO2 > 70%

IF flow is too low: 1. Infuse more volume 2. reposition venous cannula 3. add a venous cannula

2. Arterial Blood Gas Analysis:

  • GOAL:  “normal” ABG (PaO2 80-100; PaCO2 35-45)

IF PaO2 < 80,   THEN you need more blood flow through the Oxygenator

IF PaO2 > 100, THEN its time to add a gas blender and turn down the FiO2 from the Oxygen source

IF PaCO2 < 35, THEN decrease your “Sweep Gas Rate” by lowering the LPM on the O2 supply

IF PaCO2 > 45, THEN increase your “Sweep Gas Rate” by increasing the LPM on the O2 supply

 

3. Optimize Systemic Vascular Resistance (SVR)

SVR = (MAP – CVP) x 80
C.O.

SVR = (MAP – 0)      x 80
Blood Flow

***GOAL = SVR > 800

IF, for a given blood flow, the MAP is unreasonably low, you need a pure VASOPRESSOR = Phenylephrine

IF, for a given blood flow, the MAP is unreasonably HIGH, you need a VASODILATOR = Nitroprusside

Or, Goal MAP > 65

 

 The Shinar 3000: Tall Paul ECMO Simulator

Zack built an ECMO simulator model in his garage. Here is the video:

Tall Paul Compilation 3 from Joe Bellezzo on Vimeo.

EDECMO 19 – ECPR for Out-of-Hospital Cardiac Arrest Japanese-Style!

SakamotoTetsuya Sakamoto is the principal investigator of a multi-center prospective observational study comparing ECPR vs. traditional resuscitation for out of hospital cardiac arrest. His study was just recently published in the journal Resuscitation: Resuscitation. 2014 Jun;85(6):762-8. Zack and Joe met with Dr. Sakamoto during the 2014 AHA RESS conferences and talked all things ECPR.  After that, Shinar sat down with Dr. Sakamoto to get his take on how the Japanese EMS system is setup and how they are able to implement ECPR into their resuscitation protocols.

 

The Japanese Emergency Care System

  • Ambulance Crew = 1 EMT paramedic + 2 EMT's
    • EMT paramedic
      • Epi
      • Intubate
    • 2 Basic-trained EMT's
  • Hospital Systems:
    • General Hospital
    • Tertiary Hospital Receiving Centers (271 Centers)
      • Trauma
      • Resuscitation
      • Critical Care
  • Emergency Department at Japanese Tertiary Care Center
    • Emergency ICU
    • Trauma resuscitation, PCI, etc.
  • Pre-hospital protocols for Termination of Resuscitation protocols in Japan
    • In Japan, prehospitals providers are not empowered to pronounce
    • Average time on Scene = 10-20 min (scoop and run!)
    • They transport everyone!

Percutaneous Cardiopulmonary Support (ECMO) and the Save-J team

Final Thoughts

  • ECPR has huge promise for saving the lives of patients who would otherwise not survive with standard ACLS. But the cost is not trivial. So,
    1. we need to drill down into the inclusion criterion to ensure we are using this therapy on patients who will gain the most benefit.
    2. ECPR requires a team-approach, much like a trauma team activation.  The successful ECPR team still demands good-quality chest compressions, appropriate use of ACLS protocols, etc.
    3. Training is important because cannulation during arrest is tough.
  •  The Save-J approach to cannulation:   much like we do it here in the US, ultrasound-guided percutaneous approach is usually the go-to approach, with cut-down used as a rescue intervention.
*The EDECMO authors would like to thank Tetsuya Sakamoto for joining us on this episode of the EDECMO podcast and allowing us to share his thoughts on ECPR.

 

…No sex, no drugs, no wine, no women, no fun, no sin, no you, no wonder its dark…

~The Vapors (1980)

EDECMO 18 – Remote Ischemic Conditioning – with Graham Nichol

Remote Ischemic Conditioning to Reduce Ischemia-Reperfusion Injury after Cardiac Arrest

In this episode Zack and Joe talk with a true pioneer in resuscitation and the science of cardiac arrest management. Graham Nichol, from the University of Washington,  joined us at Sharp Memorial Hospital for an amazing discussion about “Remote Ischemic Conditioning” and its role in prevention of ischemia-reperfusion injury resulting from cardiac arrest.  Is this VooDoo or a real phenomenon? Listen to this episode to find out…

Some Definitions:

  • “Ischemia-Reperfusion” injury:  prolonged ischemia to the brain and heart often occur after circulatory arrest. Immediate CPR minimizes this phenomenon but many of our patients who arrest in the pre-hospital setting don't receive immediate bystander CPR, resulting in prolonged ischemia. CPR reintroduces blood flow and oxygen to the previously ischemic tissues.  This hyperoxic ‘reperfusion' is known to be a main contributor to infarct size in  both the heart and brain causing poor neurologic outcomes after arrest. Minimizing this reperfusion injury is major focus of resuscitative science right now.
  • “Ischemic Conditioning”: purposeful application of ischemia and reperfusion, off and on, to the tissues.
    • “Pre-conditioning” = applying this therapy BEFORE circulatory arrest
    • “Peri-conditioning” = applying this therapy either DURING circulatory arrest
    • “Post-conditioning” = applying this therapy AFTER circulatory arrest
  • “Targeted” vs. “Remote” Ischemic Conditioning:
       “Targeted” ischemic conditioning: application of conditioning directly to the  specific target organ (ie the heart or the brain). This can be done in one of two ways:

    • systemic  ischemic conditioning.
      • In a pig model of cardiac arrest, Demetris Yannapoulos and Keith Lurie applied brief periods of ischemic post-conditioning via “Stutter CPR” (3-4 cycles of 20 seconds of CPR with 20 second pauses) after prolonged “no flow” arrest – upwards of 20 minutes without CPR – and found normal LV function and elimination of ischemic insult to the brain using this technique.   They discussed this controversial topic with Weingart on the emcrit podcast Episode 69.
    • Local conditioning: applying ischemic conditioning directly to the target organ
      • Many studies have shown effectiveness of local ischemic conditioning during PCI for acute MI.  After restoration of vessel patency, reperfusion was interrupted by cycles of 1 min of coronary balloon reocclusion. Here is a good summary:

 “Remote ischemic conditioning: application of ischemic conditioning to a REMOTE area of the body (ie the limb) to reduce the degree of injury to the heart and brain that results from cardiac arrest (ischemia) followed by reperfusion (chest compressions, ROSC, or ECMO) by applying the ‘remote' ischemia-reperfusion by using a blood pressure cuff on a limb.

How it Works:

*courtesy of the Lancet Vol 374; Oct 2009

*courtesy of the Lancet Vol 374; Oct 2009

Several theories exist to explain the benefit of ischemic conditioning. I'll break it down in two ways:

1.)  Simple explanation: “good humors” are released from the ischemic limb and protect against cell death/apoptosis in the heart and brain.

2.) Complex hypothesis:

1.) RIC induces a cascade of intracellular kinases and modifies mitochondrial function within the cell by opening ATP-sensitive potassium channels and closing the mitochondrial permeability transition pore. 2.) RIC causes release and transport of micro-RNA-144 from the ischemic limb.  Amongst other effects, miRNA-144 effevely down-regulates protein expression involved in apoptosis, autophagy, and survival signaling. Supernerds, if you really want more on this:

Przyklenk Basic Res Cardiol 2014 RIC microRNA

role of mitochondria in protection of the heart by preconditioning Halestrap 2007

How its Done:

  1. On any limb, inflate a simple blood pressure cuff to a pressure above the systolic blood pressure. 200 mmHg is a good starting point. If you are using a manual cuff, Graham recommends clamping a Kelly on the tubing to prevent deflation of the cuff too soon.
  2. Keep the cuff inflated for 5 min and then deflate for 5 min.
  3. Do 3-4 cycles of this, and you're done.

 

The Evidence:

  1.  Xu Crit Care Med 2015 Conditioning in Rat Model of Cardiac Arrest  – In rats, better myocardial and cerebral function with longer duration of survival occurred when RIC was applied prior to arrest (preconditioning), at the time of arrest, or after arrest (arrest) when compared to controls (no conditioning). This take-home from this study was that the conditioning did not have to occur before the arrest; benefit was seen if conditioning were applied intra-arrest or post-arrest.  Application: RIC appears to be beneficial even if done after ROSC.
  2. Sloth Eur Heart J 2013 Long Term RIC – In humans, RIC before PCI improved long term clinical outcomes in patients with STEMI.
  3. Rentoukas RIC JACC CV Intervention 2010 – Remote Ischemic PERI-conditioning (applying the RIC at the time of revascularization in the cath lab) was cardioprotective.
  4. Przyklenk Basic Res Cardiol 2014 RIC microRNA – An explanation of the proposed mechanism of RIC at the cellular level; Good Humors
  5. Lancet Botker Ischemic Conditioning Trial – This is a great review paper on remote ischemic preconditioning.

Graham Nichol MD, MPH, FACP

Graham Nichol MD, MPH

Graham Nichol MD, MPH

nichol@uw.edu

@grahamnichol

Current Positions:

  • Professor of Medicine, Division of General Internal Medicine at the University of Washington in Seattle
  • Director, UW Medical Center/Harborview Medical Center for Pre-hospital Emergency Care
  • Medical Director, University of Washington Clinical Trial Center
  • Leonard A Cobb Medic One Foundation Endowed Chair in Prehospital Emergency Care
  • Medical Director, Resuscitation Outcome Consortium Clinical Trial Center

Professional Endeavors:

  • American Heart Association’s Basic Life Support Subcommittee and Advanced Life Support Subcommittee
  • chair of the Basic Life Support Subcommittee and received the American Heart Association Award of Merit
  • chair of the Basic Life Support Subcommittee and received the American Heart Association Award of Merit
  • Co-founded and  co-directed the Resuscitation Science Symposium (ReSS) of the American Heart Association
  • National Institutes of Health (NIH) reviewer and a grantee
  • chair of the epidemiology panel for the National Heart Lung and Blood Institute-sponsored PULSE conference and PULSE leadership group
  • co-principal investigator of the Resuscitation Outcomes Consortium (ROC) Data Coordinating Center
  • co-investigator of the Australian Resuscitation Outcomes Consortium

 TrackBacks

LITFL Reviews Episode 164

LITFL Reviews Episode 164


 

More with Graham Nichol

Death Ride

Death Ride

Graham is an avid cyclist and attributes his ability to ride more than 100 miles and climb more than 10,000 feet in a day to his off-label use of remote ischemic conditioning!  Here, he and a friend are about to begin the long ride up Carson Pass to finish the Death Ride.

 Upcoming Events

CastleFest: April 14-16, 2015

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CCUS Montreal: May 1-3, 2015

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SMACC Chicago 2015: June 23-26, 2015

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Recording EDECMO 18  EDECMO World Headquarters San Diego, CA

Recording EDECMO 18
EDECMO World Headquarters
San Diego, CA

EDECMO 17 – The Reanimateur: Lionel Lamhaut on Pre-Hospital ECPR

Lamhaut

Dr. Lionel Lamhaut

In this episode Zack sits down with Dr. Lionel Lamhaut, an anesthesiologist and “reanimateur” from Paris, France, about their pre-hospital ECMO program. Yes. You read that right. This group from France is  sending an ECMO team to the scene of the cardiac arrest and, in appropriate cases, initiating ECMO in the field.  Does this really work? What are the logistics of making this happen? Is this the future of pre-hospital resuscitation? Does this model translate to EMS models in other countries?  And most importantly, does this finally challenge the despicable “Termination of Resuscitation” (TOR) policies that have been metastasizing throughout our EMS communities?

The Plague of the TOR:

In the U.S. the “Termination of  Resuscitation” (TOR) policies are plaguing our pre-hospital colleagues. By TOR ideology, paramedics arrive to the scene of an arrested patient and work the patient until either ROSC or death.  This is the “stay and play” model at its extreme.  They simply don't transport patients to the hospital unless they achieve ROSC in the field.  No ROSC = No transport.  Dead.   We have become victims of our own success; Paramedics are now so good that they can do (almost) everything in the field that could be done at the hospital.  And, as the argument goes, transporting patients only results in: 1.) lesser-quality chest compressions, 2.) potential EMS/rescuer injury (by not being strapped into their safety harnesses during transport), 3.) inherent public dangers in transporting patients “Code 3” (lights and sirens), etc.  In other words, Emergency Departments traditionally couldn't offer anything that medics could not offer in the field and the quality and safety of the patient and the rescuers was worse because of the transport.

Well…that all changes with ECMO.  Here are the three current options:

  1. San Diego:  In our Emergency Department Emergency Physicians initiate ECMO.  We still suffer from the policies of TOR but try to encourage our EMS team to consider transport of certain patients.
  2. Australia (CHEER), rescuers initiate CPR with a mechanical chest compression device, begin intra-arrest cooling, and transport immediately to their ECMO/CPB center (The Alfred Hospital in Melbourne). For more on CHEER and the Alfred Hospital in Melbourne, Australia, check out Part 1 of our interview with Dr. Stephen Bernard on EDECMO Episode 14.  And Part 2 of our interview with Dr. Bernard was EDECMO Episode 15.
  3. France: Pre-Hospital ECMO.  Hell, the word “Reanimation” is painted right on the front of the ambulances in Paris!    This is what this episode of the EDECMO podcast is all about.

 

Mobile ICU = First responders

-physician on ambulance

-“Exactly like trauma room”

Prehospital ECMO Team

– 2 senior non-surgeon physicians with expertise in ECMO, 1 nurse, 1 paramedic

– Maquet™ Cardiohelp

– 2 units of packed RBCs and 2 units of FFP

– Sedation

– Therapeutic Hypothermia

Approach

– Seldinger technique with modified cutdown of proximal vessels. They FIRST do a cutdown to expose the femoral vessels. They then insert the needle DISTAL to the femoral cutdown and visualize direct vessel access within the open surgical field.  That way, the cannulas are actually placed percutaneous while vessel access can be directly visualized. Lionel says that this approach is actually faster and safer than just blindly stabbing around with the needle as is done with a blind percutaneous method. Hybrid seldinger

Inclusion Criteria

– Physician on scene makes assessment

– Positive bystander of CPR

– Younger people

– Shockable rhythm better

Ideology

– Out of hospital cardiac arrest survivorship should be the same as In-hospital cardiac arrest

– Need to decrease low flow state (shorten the time patients need chest compressions by getting them on the pump ASAP)

– 20 minutes to bypass in the field from arrival of prehospital ECMO team

– This gives you bypass of less than 60 minutes

– “Load and Go” is not fast enough

Results

– 10% survival from prehospital ECMO

– ECMO is a “Bridge to Neurologic Assessment”

– Organ Donation

Examples of Pre-hospital ECMO*

ECMO at the Louvre

ECMO at the Louvre

ECMO in the Supermarket

ECMO in the Supermarket

ECMO in the street

ECMO in the street

ECMO in the Subway

ECMO in the Subway

(*photos courtesy of Lionel Lamhaut)

Two Articles By Lamhaut:

Successful treatment of refractory cardiac arrest by emergency physicians using pre-hospital ECLS

Safety and feasibility of prehospital extra corporeal life support implementation by non-surgeons for out-of-hospital refractory cardiac arrest

Want More?

EDECMO 14: The CHEER Trial with Dr. Stephen Bernard

EDECMO 15: Part 2 of our interview with Dr. Stephen Bernard

INTENSIVE: The Alfred Hospital's amazing ECMO site

EDECMO 16: The End-of-Life Matrix & The Ethics of Advanced Resuscitation with Dr. Cyrus P. Olsen III, D.Phil.

In this episode, Zack and Joe talk with Dr. Cyrus Olsen, Oxford graduate and expert in bioethics about how to decide when to “Stop the Train”.

 


WARNING: This is going to get waaaaay touchy-feely and waaaaay outside of Joe's comfort zone (Zack, on the other hand, is feeling right at home here). With that in mind…

“How young is too young…” to withhold resuscitation?

The Dilemmas:

  1. How old is too old…or better yet…how young is too young?  aside from routine resuscitation: drugs, chest compressions, shocks, is there an age that is too old for ECMO? We currently use a soft cutoff of 75 yoa. Lets take all of the variables out of the equation and just assume a person has ZERO medical problems and is on ZERO medications. They ambulate on their own, live independently, and they believe they have a good quality of life.  In this scenario, is there any age that is too old for ECMO? This should be our starting point and then move down (in age) from there.  The 95 year old is easy.  The 40 year old is easy. All the rest are tough and that's where we will get criticism for “doing too much.”
  2. Concrete resuscitation cutoff vs. a graded response?  Whatever we decide is the cutoff (age, quality of life, comorbidities), should we use the exact same set of criteria for even initiating CPR as we do for ECMO? Should they be the same? In other words, should we have the same set of criteria for both or should there be a graded response to the dying patient (over 75 I do CPR and intubate but don't do ECMO but under 75 I go full-court-press and possible ECMO)?
  3. Only Reverse the Reversible. Somehow we need to identify inevitable death and allow that to happen. Greg Henry always says, “Despite all the advances of modern medicine, the death remains the same: one per person.”  But when we can't be sure that death is inevitable, does everyone deserve a shot?  In other words, should we be making that decision on the front end (ED) when little information is known to us, or should that be sorted out on the back end…in the ICU?  Is there a way to tell a resuscitationist that its ok to err on the side of over-resuscitation, so long as your intent to is to reverse the reversable? Peter Safar's quote, “Death is not the enemy, but occasionally need help with timing.” exemplifies this.
  4. Define “Quality of Life”. How do we determine “Quality of Life”? Who decides this in the heat of the moment? The doctor or the family?
  5. What is the real goal of resuscitation? Should we only resuscitate people who were previously healthy and have a chance of 100% recovery? It seems we've come to a place where the knee-jerk reaction by ED doctors is to do full CPR on everyone and then see what happens.  So how do we determine when and where to stop?
  6. MD paternalism vs. patient automony = “The Tyranny of Choice.”

 

The Episode Play-by-Play:

Dr. Olsen talks about the first concept: The “3 Senses of Dignity” from Daniel Sulmasy MD, PhD, a spokesman for the President's Council on Biotheics

  1. Intrinsic Dignity = your value for just being human
  2. Attributed Dignity = your “market value” to society
  3. Inflorescent Dignity = your “flourishing”; or your quality of life

Utstein Variables for CPR

 The Life Matrix and the Functional Threshold:

Life Matrix

“We cannot predict the neurologic outcome of patients that are in cardiac arrest” – Zack Shinar MD

Bottom line: As a resuscitationist in the Emergency Department you MUST err on the side of aggressive curative care, unless there is compelling evidence to do otherwise.  You are on ethical solid-ground to approach resuscitation in this fashion. But…you will fuck this up. And that's ok if your heart is in the right place. And once you realize that your patient does not belong in the AGGRESSIVE CURATIVE arm, you begin AGGRESSIVE PALLIATIVE care. In either case, you care is MAXIMALLY AGGRESSIVE.  

Joe & Zack recording

Joe & Zack recording

 

 


Dr. Cyrus P. Olsen III, D.Phil.

Dr. Cyrus P. Olsen III, D.Phil.

Dr. Cyrus P. Olsen, D.Phil.

Dr. Olsen is a graduate of the University of Oxford and is now an Associate Professor at The University of Scranton, in Pennsylvania where he specializes in Ethics and Theologic Studies. He has published extensively in the arena of medical ethics and sits on the IRB (Institutional Review Board) for both human and animal studies at his institution. A graduate of the Comparative History of Ideas Program at The University of Washington, and Systematic Theology from The University of Oxford, his research and teaching address many aspects of human studies and bioethics.

 


Medical Journal Articles on the Ethics of Resuscitation Discussed in this Episode

Circulation- Ethics of CPR

Ethics of Resuscitation – Hayes

Freedom from the Tyranny of Choice

Br. J. Anaesth.-1997-Mohr-253-9

IMG_8217_2


 

Trackbacks:

1. Emcrit Podcast 25: End of Life and Palliative Care in the ED – Scott Weingart from the Emcrit Podcast

2. Emcrit Podcast 93: Critical Care Palliation with Ashley Shreves