56: Pressors, Fluid, or Flow – Optimizing ECMO Physiology

A post arrest patient just got initiated on ECMO.  Do you give fluids, add pressors, or increase flow?  Marc Dickstein, an anesthesiologist from Columbia University and an expert in the physiology of ECMO, talks with Zack about how to manage these patients, what diagnostics we need and how to optimize your use of the machine.  This talk is a must for everyone starting ECPR in their departments.

Photo: Marc Dickstein

Marc's ECMO physiology website Harvi

Marc's ASAIO article on ECMO physiology –

Dickstein ML. The Starling Relationship and Veno-Arterial ECMO: Ventricular Distension Explained. ASAIO J. 2018 Jul/Aug;64(4):497-501. doi: 10.1097/MAT.0000000000000660. PubMed PMID: 29076945.

Zack's recent Resus Editorial on Impella

Shinar Z. Is the "Unprotected Heart" a clinical myth? Use of IABP, Impella,
and ECMO in the acute cardiac patient. Resuscitation. 2019 May 21. pii:
S0300-9572(19)30173-X. doi: 10.1016/j.resuscitation.2019.05.005. [Epub ahead of
print] PubMed PMID: 31125528

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Waleed SneijDavid HerseyMarc DicksteinJohn Stokes Recent comment authors
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John Stokes
John Stokes

Great episode and love the discussion. Wanted to add a simple point that I didn’t hear mentioned. It may have not been mentioned because it is obvious to everyone. Lots of discussion about whether the aortic valve is opening and adjusting flow, pre-load, after-load to get the valve opening. Remember the simplest, real-time way to assess whether the valve is opening is your right radial or axillary arterial line. The patient needs it anyway. If you have a pulsatile waveform on that arterial line, the valve is opening. If you don’t have a pulsatile waveform, the valve isn’t opening. Additionally,… Read more »

Marc Dickstein
Marc Dickstein

Great comments. Spot on! What you mention is so important, it’s worth repeating: No pulsatility on the a-line means there’s no ejection. But if there is pulsatility (ie ejection), you still need to determine the filling pressure required for the LV to eject; could be reasonable (pcwp in the teens) or it could be unacceptably high. No way of knowing that from the a-line waveform. And a distended ventricle won’t recover, and acute pulmonary edema really complicates management!

David Hersey
David Hersey


Excellent podcast. It is going to take me awhile to work through this one.

Keep up the hard work because the Reanimate Conference and this podcast is making a difference (not sure how you find the time!).

With luck, Dr. James Gould, will be getting our own ‘Code ECMO’ program up and running here in Nova Scotia.

Waleed Sneij
Waleed Sneij

Love the podcast. Thank you for taking the time to do it. I’m still struggling with CVP measurements once on VA ECMO. Would you elaborate on this some more? In my mind adding a parallel circuit (with ECMO) would lower RV filling pressures but it does not seem to be the case? I’m thinking about RV failure from PE for example.